Hip vs Hype: Research Frontiers in Agentic AI and Foundation Models

Agentic AI systems and foundation models are rapidly becoming central to the future of medical AI research, with proposed applications across imaging, reporting, clinical decision support, workflow orchestration, patient communication, and real-world deployment. Yet the field is still early, and many claims remain difficult to evaluate. Performance may depend on benchmark design, data leakage, prompt sensitivity, model access, evaluation strategy, clinical context, and the degree of human oversight. 

This interactive CAIMI research session will use a “Hip vs Hype” format to critically examine emerging directions in agentic AI and foundation models. Rather than focusing only on what is new or exciting, the discussion will ask what evidence is needed to determine whether these approaches represent meaningful scientific progress, translational opportunity, or premature enthusiasm. 

Using polls, participants will vote on key topics in agentic AI and foundation models, including autonomous clinical agents, multi-agent workflows, AI-assisted reporting, patient-facing systems, model evaluation, safety monitoring, and governance. Each poll will be followed by brief commentary and audience discussion focused on research gaps, methodological limitations, clinical relevance, and opportunities for collaborative study. 

The goal of the session is to create a dynamic, audience-driven conversation that helps researchers distinguish promising frontiers from under-validated claims and identify rigorous research questions for the next phase of medical AI. 

Objectives

Critically evaluate emerging applications of agentic AI and foundation models in medicine using research-focused evidence standards. 

Identify methodological limitations in current studies, including benchmark contamination, lack of external validation, prompt sensitivity, limited clinical endpoints, and insufficient prospective evaluation. 

Describe how agentic AI introduces new research questions around autonomy, orchestration, reliability, human oversight, accountability, and safety. 

Discuss the opportunities and limitations of foundation models for imaging, reporting, multimodal reasoning, patient communication, and clinical workflow support. 

Speakers

Headshot of Kathy Andriole

Katherine P. Andriole, PhD, FSIIM 

Associate Dean for Health AI Strategy & Innovation, UCLA David Geffen School of Medicine  
Director, UCLA Center for AI and SMART Health

Headshot of Tessa Cook, MD, PhD, CIIP, FSIIM

Tessa Cook, MD, PhD, CIIP, FSIIM 

Associate Professor of Radiology, Vice Chair of Informatics 
Perelman School of Medicine at the University of Pennsylvania 

Daye Dania

Dania Daye, MD, PhD 

Vice Chair of Practice Transformation, Director of the Center for High Value Imaging (CHVI), Associate Professor of Interventional Radiology 
University of Wisconsin School of Medicine and Public Health 

Satvik Tripathi Profile

Satvik Tripathi 

Doctoral Student, Researcher in the Department of Radiology & Radiation Oncology 
Fellow, Penn Center for Cancer Care Innovation  

SESSION ID

1004


DATE

MON, OCT 26


TIME

1:00 PM – 1:45 PM ET


LOCATION

Smilow Rubenstein Auditorium 


CONTINUING EDUCATION

ASRT-RT | CAMPEP-MPCEC | SIIM IIP-CIIP